CC-115

Product Name: CC-115
CAS No.: 1228013-15-7
Chemical Name: CC-115
Synonyms: CC-115;CS-2038;CC-115, >95%;CC115;CC 115;CC-115(free base);DNA-dependent protein kinase,inhibit,CC115,CC-115,DNA-PK,mTOR,Inhibitor,Mammalian target of Rapamycin;1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one;1-Ethyl-7-(2-methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one;Pyrazino[2,3-b]pyrazin-2(1H)-one, 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-
CBNumber: CB03041392
Molecular Formula: C16H16N8O
Formula Weight: 336.35
MOL File: 1228013-15-7.mol

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CC-115 Property

Boiling point:: 587.3±60.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥50 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form: solid
pka: 5.94±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19420
Product name: CC-115
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19420
Product name: CC-115
Purity: ≥95%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 19420
Product name: CC-115
Purity: ≥95%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 19420
Product name: CC-115
Purity: ≥95%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

ChemScene

Product number: CS-4561
Product name: CC-115
Purity: 96.64%
Packaging: 10mg
Price: $150
Updated: 2021/12/16

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CC-115 Chemical Properties,Usage,Production

Biological Activity

cc-115 is a inhibitor of mtor/dna-pk.the mammalian target of rapamycin (mtor) kinase is a key mediator of the phosphoinositide 3-kinase /protein kinase b (akt pathway). the dna-dependent protein kinase (dna-pk) is a critical component of the dna repair machinery governings the response to dna damage, which serves to maintain genome integrity.

in vitro

previous study found that the proliferation induced by cd40(+) interleukin-21 stimulation could be completely blocked by cc-115, and cd40-mediated resistance to fludarabine and venetoclax could also be reverted by cc-115. moreover, bcr-mediated signaling was blocked by cc-115 and in cll samples from patients with acquired resistance to idelalisib treatment [1].

in vivo

preclinical studies showed that cc-115 had good in vivo pk profiles across multiple species with 53%, 76%, and around100% oral bioavailability in mouse, rat, and dog, respectively [2].

target

Target	Value
DNA-PK (Cell-free assay)	0.013 μM
mTOR (Cell-free assay)	0.021 μM
PI3Kα (Cell-free assay)	0.852 μM

IC 50

21/ 13 nm for mtor/dna-pk

References

[1] thijssen r,et al. dual tork/dna-pk inhibition blocks critical signaling pathways in chronic lymphocytic leukemia. blood.2016 jul 28;128(4):574-83.
[2] mortensen ds, et al. optimization of a series of triazole containing mammalian target of rapamycin (mtor) kinase inhibitors and the discovery of cc-115. j med chem. 2015 jul 23;58(14):5599-5608.

CC-115 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC-115 Suppliers

China 61 India 1 United States 8 Global 70

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

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View Lastest Price from CC-115 manufacturers

Career Henan Chemical Co

Product: CC-115 1228013-15-7
Price: US $1.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

1228013-15-7, CC-115Related Search:

CS-2038

CC115;CC 115

CC-115, >95%

CC-115(free base)

1-Ethyl-7-(2-methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one

CC-115

1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one

Pyrazino[2,3-b]pyrazin-2(1H)-one, 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-

DNA-dependent protein kinase,inhibit,CC115,CC-115,DNA-PK,mTOR,Inhibitor,Mammalian target of Rapamycin

1228013-15-7